Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection.
Identifieur interne : 000069 ( Main/Exploration ); précédent : 000068; suivant : 000070Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection.
Auteurs : Jeffrey C. Kwong [Canada] ; Kevin L. Schwartz [Canada] ; Michael A. Campitelli [Canada] ; Hannah Chung [Canada] ; Natasha S. Crowcroft [Canada] ; Timothy Karnauchow [Canada] ; Kevin Katz [Canada] ; Dennis T. Ko [Canada] ; Allison J. Mcgeer [Canada] ; Dayre Mcnally [Canada] ; David C. Richardson [Canada] ; Laura C. Rosella [Canada] ; Andrew Simor [Canada] ; Marek Smieja [Canada] ; George Zahariadis [Canada] ; Jonathan B. Gubbay [Canada]Source :
- The New England journal of medicine [ 1533-4406 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Femelle, Grippe humaine (), Grippe humaine (diagnostic), Hospitalisation (), Humains, Incidence, Infarctus du myocarde (épidémiologie), Infarctus du myocarde (étiologie), Mâle, Ontario (épidémiologie), Risque, Sujet âgé, Sujet âgé de 80 ans ou plus, Virus de la grippe A (isolement et purification), Virus influenza B (isolement et purification).
- MESH :
- diagnostic : Grippe humaine.
- isolement et purification : Virus de la grippe A, Virus influenza B.
- épidémiologie : Infarctus du myocarde, Ontario.
- étiologie : Infarctus du myocarde.
- Adulte d'âge moyen, Femelle, Grippe humaine, Hospitalisation, Humains, Incidence, Mâle, Risque, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Female, Hospitalization (statistics & numerical data), Humans, Incidence, Influenza A virus (isolation & purification), Influenza B virus (isolation & purification), Influenza, Human (complications), Influenza, Human (diagnosis), Male, Middle Aged, Myocardial Infarction (epidemiology), Myocardial Infarction (etiology), Ontario (epidemiology), Risk.
- MESH :
- complications : Influenza, Human.
- diagnosis : Influenza, Human.
- epidemiology : Myocardial Infarction, Ontario.
- etiology : Myocardial Infarction.
- isolation & purification : Influenza A virus, Influenza B virus.
- statistics & numerical data : Hospitalization.
- Aged, Aged, 80 and over, Female, Humans, Incidence, Male, Middle Aged, Risk.
Abstract
BACKGROUND
Acute myocardial infarction can be triggered by acute respiratory infections. Previous studies have suggested an association between influenza and acute myocardial infarction, but those studies used nonspecific measures of influenza infection or study designs that were susceptible to bias. We evaluated the association between laboratory-confirmed influenza infection and acute myocardial infarction.
METHODS
We used the self-controlled case-series design to evaluate the association between laboratory-confirmed influenza infection and hospitalization for acute myocardial infarction. We used various high-specificity laboratory methods to confirm influenza infection in respiratory specimens, and we ascertained hospitalization for acute myocardial infarction from administrative data. We defined the "risk interval" as the first 7 days after respiratory specimen collection and the "control interval" as 1 year before and 1 year after the risk interval.
RESULTS
We identified 364 hospitalizations for acute myocardial infarction that occurred within 1 year before and 1 year after a positive test result for influenza. Of these, 20 (20.0 admissions per week) occurred during the risk interval and 344 (3.3 admissions per week) occurred during the control interval. The incidence ratio of an admission for acute myocardial infarction during the risk interval as compared with the control interval was 6.05 (95% confidence interval [CI], 3.86 to 9.50). No increased incidence was observed after day 7. Incidence ratios for acute myocardial infarction within 7 days after detection of influenza B, influenza A, respiratory syncytial virus, and other viruses were 10.11 (95% CI, 4.37 to 23.38), 5.17 (95% CI, 3.02 to 8.84), 3.51 (95% CI, 1.11 to 11.12), and 2.77 (95% CI, 1.23 to 6.24), respectively.
CONCLUSIONS
We found a significant association between respiratory infections, especially influenza, and acute myocardial infarction. (Funded by the Canadian Institutes of Health Research and others.).
DOI: 10.1056/NEJMoa1702090
PubMed: 29365305
Affiliations:
Links toward previous steps (curation, corpus...)
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection.</title><author><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Schwartz, Kevin L" sort="Schwartz, Kevin L" uniqKey="Schwartz K" first="Kevin L" last="Schwartz">Kevin L. Schwartz</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Campitelli, Michael A" sort="Campitelli, Michael A" uniqKey="Campitelli M" first="Michael A" last="Campitelli">Michael A. Campitelli</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Chung, Hannah" sort="Chung, Hannah" uniqKey="Chung H" first="Hannah" last="Chung">Hannah Chung</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Karnauchow, Timothy" sort="Karnauchow, Timothy" uniqKey="Karnauchow T" first="Timothy" last="Karnauchow">Timothy Karnauchow</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ko, Dennis T" sort="Ko, Dennis T" uniqKey="Ko D" first="Dennis T" last="Ko">Dennis T. Ko</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mcgeer, Allison J" sort="Mcgeer, Allison J" uniqKey="Mcgeer A" first="Allison J" last="Mcgeer">Allison J. Mcgeer</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mcnally, Dayre" sort="Mcnally, Dayre" uniqKey="Mcnally D" first="Dayre" last="Mcnally">Dayre Mcnally</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Richardson, David C" sort="Richardson, David C" uniqKey="Richardson D" first="David C" last="Richardson">David C. Richardson</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rosella, Laura C" sort="Rosella, Laura C" uniqKey="Rosella L" first="Laura C" last="Rosella">Laura C. Rosella</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Simor, Andrew" sort="Simor, Andrew" uniqKey="Simor A" first="Andrew" last="Simor">Andrew Simor</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Smieja, Marek" sort="Smieja, Marek" uniqKey="Smieja M" first="Marek" last="Smieja">Marek Smieja</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Zahariadis, George" sort="Zahariadis, George" uniqKey="Zahariadis G" first="George" last="Zahariadis">George Zahariadis</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29365305</idno><idno type="pmid">29365305</idno><idno type="doi">10.1056/NEJMoa1702090</idno><idno type="wicri:Area/Main/Corpus">000060</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000060</idno><idno type="wicri:Area/Main/Curation">000060</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000060</idno><idno type="wicri:Area/Main/Exploration">000060</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection.</title><author><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Schwartz, Kevin L" sort="Schwartz, Kevin L" uniqKey="Schwartz K" first="Kevin L" last="Schwartz">Kevin L. Schwartz</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Campitelli, Michael A" sort="Campitelli, Michael A" uniqKey="Campitelli M" first="Michael A" last="Campitelli">Michael A. Campitelli</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Chung, Hannah" sort="Chung, Hannah" uniqKey="Chung H" first="Hannah" last="Chung">Hannah Chung</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Karnauchow, Timothy" sort="Karnauchow, Timothy" uniqKey="Karnauchow T" first="Timothy" last="Karnauchow">Timothy Karnauchow</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ko, Dennis T" sort="Ko, Dennis T" uniqKey="Ko D" first="Dennis T" last="Ko">Dennis T. Ko</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mcgeer, Allison J" sort="Mcgeer, Allison J" uniqKey="Mcgeer A" first="Allison J" last="Mcgeer">Allison J. Mcgeer</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mcnally, Dayre" sort="Mcnally, Dayre" uniqKey="Mcnally D" first="Dayre" last="Mcnally">Dayre Mcnally</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Richardson, David C" sort="Richardson, David C" uniqKey="Richardson D" first="David C" last="Richardson">David C. Richardson</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rosella, Laura C" sort="Rosella, Laura C" uniqKey="Rosella L" first="Laura C" last="Rosella">Laura C. Rosella</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Simor, Andrew" sort="Simor, Andrew" uniqKey="Simor A" first="Andrew" last="Simor">Andrew Simor</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Smieja, Marek" sort="Smieja, Marek" uniqKey="Smieja M" first="Marek" last="Smieja">Marek Smieja</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Zahariadis, George" sort="Zahariadis, George" uniqKey="Zahariadis G" first="George" last="Zahariadis">George Zahariadis</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name><affiliation wicri:level="4"><nlm:affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</nlm:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Hospitalization (statistics & numerical data)</term><term>Humans</term><term>Incidence</term><term>Influenza A virus (isolation & purification)</term><term>Influenza B virus (isolation & purification)</term><term>Influenza, Human (complications)</term><term>Influenza, Human (diagnosis)</term><term>Male</term><term>Middle Aged</term><term>Myocardial Infarction (epidemiology)</term><term>Myocardial Infarction (etiology)</term><term>Ontario (epidemiology)</term><term>Risk</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (diagnostic)</term><term>Hospitalisation ()</term><term>Humains</term><term>Incidence</term><term>Infarctus du myocarde (épidémiologie)</term><term>Infarctus du myocarde (étiologie)</term><term>Mâle</term><term>Ontario (épidémiologie)</term><term>Risque</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Virus de la grippe A (isolement et purification)</term><term>Virus influenza B (isolement et purification)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Myocardial Infarction</term><term>Ontario</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de la grippe A</term><term>Virus influenza B</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infarctus du myocarde</term><term>Ontario</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infarctus du myocarde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Risk</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Grippe humaine</term><term>Hospitalisation</term><term>Humains</term><term>Incidence</term><term>Mâle</term><term>Risque</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Acute myocardial infarction can be triggered by acute respiratory infections. Previous studies have suggested an association between influenza and acute myocardial infarction, but those studies used nonspecific measures of influenza infection or study designs that were susceptible to bias. We evaluated the association between laboratory-confirmed influenza infection and acute myocardial infarction.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We used the self-controlled case-series design to evaluate the association between laboratory-confirmed influenza infection and hospitalization for acute myocardial infarction. We used various high-specificity laboratory methods to confirm influenza infection in respiratory specimens, and we ascertained hospitalization for acute myocardial infarction from administrative data. We defined the "risk interval" as the first 7 days after respiratory specimen collection and the "control interval" as 1 year before and 1 year after the risk interval.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We identified 364 hospitalizations for acute myocardial infarction that occurred within 1 year before and 1 year after a positive test result for influenza. Of these, 20 (20.0 admissions per week) occurred during the risk interval and 344 (3.3 admissions per week) occurred during the control interval. The incidence ratio of an admission for acute myocardial infarction during the risk interval as compared with the control interval was 6.05 (95% confidence interval [CI], 3.86 to 9.50). No increased incidence was observed after day 7. Incidence ratios for acute myocardial infarction within 7 days after detection of influenza B, influenza A, respiratory syncytial virus, and other viruses were 10.11 (95% CI, 4.37 to 23.38), 5.17 (95% CI, 3.02 to 8.84), 3.51 (95% CI, 1.11 to 11.12), and 2.77 (95% CI, 1.23 to 6.24), respectively.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>We found a significant association between respiratory infections, especially influenza, and acute myocardial infarction. (Funded by the Canadian Institutes of Health Research and others.).</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29365305</PMID><DateCompleted><Year>2018</Year><Month>02</Month><Day>08</Day></DateCompleted><DateRevised><Year>2018</Year><Month>06</Month><Day>28</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1533-4406</ISSN><JournalIssue CitedMedium="Internet"><Volume>378</Volume><Issue>4</Issue><PubDate><Year>2018</Year><Month>Jan</Month><Day>25</Day></PubDate></JournalIssue><Title>The New England journal of medicine</Title><ISOAbbreviation>N. Engl. J. Med.</ISOAbbreviation></Journal><ArticleTitle>Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection.</ArticleTitle><Pagination><MedlinePgn>345-353</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1056/NEJMoa1702090</ELocationID><Abstract><AbstractText Label="BACKGROUND">Acute myocardial infarction can be triggered by acute respiratory infections. Previous studies have suggested an association between influenza and acute myocardial infarction, but those studies used nonspecific measures of influenza infection or study designs that were susceptible to bias. We evaluated the association between laboratory-confirmed influenza infection and acute myocardial infarction.</AbstractText><AbstractText Label="METHODS">We used the self-controlled case-series design to evaluate the association between laboratory-confirmed influenza infection and hospitalization for acute myocardial infarction. We used various high-specificity laboratory methods to confirm influenza infection in respiratory specimens, and we ascertained hospitalization for acute myocardial infarction from administrative data. We defined the "risk interval" as the first 7 days after respiratory specimen collection and the "control interval" as 1 year before and 1 year after the risk interval.</AbstractText><AbstractText Label="RESULTS">We identified 364 hospitalizations for acute myocardial infarction that occurred within 1 year before and 1 year after a positive test result for influenza. Of these, 20 (20.0 admissions per week) occurred during the risk interval and 344 (3.3 admissions per week) occurred during the control interval. The incidence ratio of an admission for acute myocardial infarction during the risk interval as compared with the control interval was 6.05 (95% confidence interval [CI], 3.86 to 9.50). No increased incidence was observed after day 7. Incidence ratios for acute myocardial infarction within 7 days after detection of influenza B, influenza A, respiratory syncytial virus, and other viruses were 10.11 (95% CI, 4.37 to 23.38), 5.17 (95% CI, 3.02 to 8.84), 3.51 (95% CI, 1.11 to 11.12), and 2.77 (95% CI, 1.23 to 6.24), respectively.</AbstractText><AbstractText Label="CONCLUSIONS">We found a significant association between respiratory infections, especially influenza, and acute myocardial infarction. (Funded by the Canadian Institutes of Health Research and others.).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kwong</LastName><ForeName>Jeffrey C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwartz</LastName><ForeName>Kevin L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campitelli</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Hannah</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crowcroft</LastName><ForeName>Natasha S</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karnauchow</LastName><ForeName>Timothy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katz</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ko</LastName><ForeName>Dennis T</ForeName><Initials>DT</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McGeer</LastName><ForeName>Allison J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McNally</LastName><ForeName>Dayre</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richardson</LastName><ForeName>David C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosella</LastName><ForeName>Laura C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simor</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smieja</LastName><ForeName>Marek</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zahariadis</LastName><ForeName>George</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gubbay</LastName><ForeName>Jonathan B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>From the Institute for Clinical Evaluative Sciences (J.C.K., K.L.S., M.A.C., H.C., D.T.K., L.C.R.), Public Health Ontario (J.C.K., K.L.S., N.S.C., L.C.R., J.B.G.), Dalla Lana School of Public Health (J.C.K., K.L.S., N.S.C., A.J.M., L.C.R.), and the Departments of Family and Community Medicine (J.C.K.) and Laboratory Medicine and Pathobiology (N.S.C., K.K., A.J.M., A.S., J.B.G.), University of Toronto, University Health Network (J.C.K.), North York General Hospital (K.K.), Sunnybrook Health Sciences Centre (D.T.K., A.S.), Sinai Health System (A.J.M.), and the Hospital for Sick Children (J.B.G.), Toronto, Children's Hospital of Eastern Ontario (T.K., D.M.) and the Department of Pathology and Laboratory Medicine, University of Ottawa (T.K.), Ottawa, William Osler Health System, Brampton, ON (D.C.R.), McMaster University, Hamilton, ON (M.S.), London Health Sciences Centre, London, ON (G.Z.), and the Newfoundland and Labrador Public Health Laboratory, St. John's (G.Z.) - all in Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>N Engl J Med</MedlineTA><NlmUniqueID>0255562</NlmUniqueID><ISSNLinking>0028-4793</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>MMW Fortschr Med. 2018 Feb;160(3):33</RefSource><PMID Version="1">29464629</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2018 Jun 28;378(26):2538-9</RefSource><PMID Version="1">29952170</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2018 Jun 28;378(26):2539</RefSource><PMID Version="1">29952171</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2018 Jun 28;378(26):2539</RefSource><PMID Version="1">29952173</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2018 Jun 28;378(26):2539-40</RefSource><PMID Version="1">29952174</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2018 Jun 28;378(26):2540</RefSource><PMID Version="1">29952175</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009203" MajorTopicYN="N">Myocardial Infarction</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009864" MajorTopicYN="N">Ontario</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29365305</ArticleId><ArticleId IdType="doi">10.1056/NEJMoa1702090</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name></region><name sortKey="Campitelli, Michael A" sort="Campitelli, Michael A" uniqKey="Campitelli M" first="Michael A" last="Campitelli">Michael A. Campitelli</name><name sortKey="Chung, Hannah" sort="Chung, Hannah" uniqKey="Chung H" first="Hannah" last="Chung">Hannah Chung</name><name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name><name sortKey="Gubbay, Jonathan B" sort="Gubbay, Jonathan B" uniqKey="Gubbay J" first="Jonathan B" last="Gubbay">Jonathan B. Gubbay</name><name sortKey="Karnauchow, Timothy" sort="Karnauchow, Timothy" uniqKey="Karnauchow T" first="Timothy" last="Karnauchow">Timothy Karnauchow</name><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name><name sortKey="Ko, Dennis T" sort="Ko, Dennis T" uniqKey="Ko D" first="Dennis T" last="Ko">Dennis T. Ko</name><name sortKey="Mcgeer, Allison J" sort="Mcgeer, Allison J" uniqKey="Mcgeer A" first="Allison J" last="Mcgeer">Allison J. Mcgeer</name><name sortKey="Mcnally, Dayre" sort="Mcnally, Dayre" uniqKey="Mcnally D" first="Dayre" last="Mcnally">Dayre Mcnally</name><name sortKey="Richardson, David C" sort="Richardson, David C" uniqKey="Richardson D" first="David C" last="Richardson">David C. Richardson</name><name sortKey="Rosella, Laura C" sort="Rosella, Laura C" uniqKey="Rosella L" first="Laura C" last="Rosella">Laura C. Rosella</name><name sortKey="Schwartz, Kevin L" sort="Schwartz, Kevin L" uniqKey="Schwartz K" first="Kevin L" last="Schwartz">Kevin L. Schwartz</name><name sortKey="Simor, Andrew" sort="Simor, Andrew" uniqKey="Simor A" first="Andrew" last="Simor">Andrew Simor</name><name sortKey="Smieja, Marek" sort="Smieja, Marek" uniqKey="Smieja M" first="Marek" last="Smieja">Marek Smieja</name><name sortKey="Zahariadis, George" sort="Zahariadis, George" uniqKey="Zahariadis G" first="George" last="Zahariadis">George Zahariadis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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